منابع مشابه
Role of Interleukin-37 in Inflammatory and Autoimmune Diseases
Interleukin-1 family 7 (IL-1F7) is a novel member of IL-1F cytokines. IL-1F7 is more commonly known as IL-37. IL-37 join the α-subunit of the IL-18 receptor, or IL-18 binding protein (IL-18BP), and binding of these proteins can enhance the IL-18 suppression. IL-37 also translocates to the cell nucleus and affects gene transcription. IL-37 inhibits the phosphorylation of p38 mitogen-activated pr...
متن کاملIL-37 restrains autoimmune diseases
Interleukin-37 (IL-37), a newly discovered member of the IL-1 family, has been identified as a natural inhibitor of immune responses [1]. The human IL-37 gene has been confirmed undergo alternative splicing and exists in five splice variants including IL-37a-e, but a mouse homologue has not been reported [2]. The most glaring is IL-37b that encodes the longest transcript variant includes exons ...
متن کاملInterleukin-32 in Inflammatory Autoimmune Diseases
Interleukin-32 (IL-32) is a cytokine inducing crucial inflammatory cytokines such as tumor necrosis factor-α (TNFα) and IL-6 and its expression is elevated in various inflammatory autoimmune diseases, certain cancers, as well as viral infections. IL-32 gene was first cloned from activated T cells, however IL-32 expression was also found in other immune cells and non-immune cells. IL-32 gene was...
متن کاملThe emerging role of interleukin‐37 in cardiovascular diseases
INTRODUCTION Interleukin (IL)-37 is a newly identified member of the IL-1 family, and shows a growing role in a variety of diseases. This review aims at summarizing and discussing the role of IL-37 in cardiovascular diseases. METHODS Data for this review were identified by searches of MEDLINE, Embase, and PubMed using appropriate search terms. RESULTS IL-37 is a newly identified cytokine be...
متن کاملInterleukin-6; pathogenesis and treatment of autoimmune inflammatory diseases
Toshio Tanaka1, 2), Masashi Narazaki3), Kazuya Masuda4) and Tadamitsu Kishimoto4,*) 1)Department of Clinical Application of Biologics, Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan 2)Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan 3)Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka Univ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: SCIENTIA SINICA Vitae
سال: 2018
ISSN: 1674-7232
DOI: 10.1360/n052017-00228